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The Potential and Challenges of Genomics Informed Precision Care for Substance Use Disorders
Substance use disorders (SUDs) are complex brain disorders with heritability rooted in the interplay of multiple genetic factors, …
Rose Mary Xavier
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GPAT1 Activity and Abundant Palmitic Acid Impair Insulin Suppression of Hepatic Glucose Production in Primary Mouse Hepatocytes
Glycerol-3-phosphate acyltransferase (GPAT) activity is correlated with obesity and insulin resistance in mice and humans. However, …
Chongben Zhang
,
Mathew Steadman
,
Hudson P Santos
,
Saame R Shaikh
,
Rose Mary Xavier
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A Retrospective Analysis of Early 20th Century Asylum Records of Patients with Dementia Praecox
Mental illness definitions and classifications are to a certain extent intrinsically tied to social factors. To empirically examine the …
Rose Mary Xavier
,
Allison M Britt
,
Brandy Reardon
,
Wales T. George
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Influences of race and clinical variables on psychiatric genetic research participation
Advances in genetics has led to a better understanding of both genetic and environmental contributions to psychiatric mental health …
Rose Mary Xavier
,
Yuktha Shanavas
,
Brian M. Britt
,
Wales T. George
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Increased Prevalence of Rare Copy Number Variants in Treatment-Resistant Psychosis
It remains unknown why ∼30% of patients with psychotic disorders fail to respond to treatment. Previous genomic investigations into …
Martialias Farrell
,
Tyler Dietterich
,
Matthew K Harner
,
Lisa M Bruno
,
Dawn M Filmyer
,
Rita A Shaughnessy
,
Maya L Lichtenstein
,
Allison M Britt
,
Tamara Bondi
,
James J Crowley
,
Gabriel Lazaro-Munoz
,
Annika E Forsingal
,
Jacob Neilsen
,
Michael Didriksen
,
Jonathan S Berg
,
Jia Wen
,
Jin Szatkiewicz
,
Rose Mary Xavier
,
Patrick F Sullivan
,
Richard C Josiassen
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Characterizing Youth-Caregiver Concordance and Discrepancies in Psychopathology Symptoms in a US Community Sample
Evidence shows that reports of psychopathology symptoms by youth and their caregiver informants differ. To quantify youth-caregiver …
Rose Mary Xavier
,
Monica E Calkins
,
Danielle S Bassett
,
Tyler M Moore
,
Wales T George
,
Rose Mary Xavier
,
Jerome H Taylor
,
Raquel E Gur
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Disorder agnostic network structure of psychopathology symptoms in youth
Background - Youth mental health disorders are strong predictors of adult mental health disorders. Early identification of mental …
Emily Wang
,
Brandy Reardon
,
Benjamin Cherian
,
Wales T. George
,
Rose Mary Xavier
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DOI
Network Structure of Youth-Collateral Discrepancies in Reported Psychopathology Symptoms
Objective- Evidence shows that reports of psychopathology symptoms from informants and youth differ. Such discrepancies are dependent …
Rose Mary Xavier
,
Monica E Calkins
,
Danielle S Bassett
,
Tyler M Moore
,
Wales T George
,
Rose Mary Xavier
,
Jerome H Taylor
,
Raquel E Gur
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Community Detection in Weighted Multilayer Networks with Ambient Noise
We introduce a novel class of stochastic blockmodel for multilayer weighted networks that accounts for the presence of a global ambient …
Mark He
,
Dylan Lu
,
Jason Xu
,
Rose Mary Xavier
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Differentiating Tardive Dyskinesia-A Video-Based Review of Antipsychotic-Induced Movement Disorders in Clinical Practice
Accurate diagnosis and appropriate treatment of tardive dyskinesia (TD) are imperative, as its symptoms can be highly disruptive to …
Robert A Hauser
,
Jonathan M Meyer
,
Stewart A Factor
,
Cynthia L Comella
,
Caroline M Tanner
,
Rose Mary Xavier
,
Stanley N Caroff
,
Leslie Lundt
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DOI
Characteristics of youth with reported family history of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort
Little is known about the impact of family history of psychosis on youth from community samples. To fill this gap, we compared youth …
Jerome H Taylor
,
Nana Asabere
,
Monica E Calkins
,
Tyler M Moore
,
Sunny X Tang
,
Rose Mary Xavier
,
Alison K Merikangas
,
Daniel H Wolf
,
Laura Almasy
,
Ruben C Gur
,
Raquel E Gur
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DOI
Implications of Antipsychotic Use - Antipsychotic-Induced Movement Disorders with a Focus on Tardive Dyskinesia
Diagnosis of antipsychotic-induced movement disorders are based on the patient’s clinical presentation in combination with a thorough …
Sattaria Dilks
,
Rose Mary Xavier
,
Crystal Kelly
,
Jessica Johnson
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DOI
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely …
Peter Brown
,
RELISH Consortium
,
Yaoqi Zhou
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DOI
Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia
Genetic etiology of psychopathology symptoms and cognitive performance in schizophrenia is supported by candidate gene and polygenic …
Rose Mary Xavier
,
Jennifer Dungan
,
Richard S E Keefe
,
Allison Vorderstrasse
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DOI
Genetic correlates of insight in schizophrenia
Schizophrenia case-only analysis of the Clinical Antipsychotics Trials of Intervention Effectiveness trial. Schizophrenia PRS was …
Rose Mary Xavier
,
Allison Vorderstrasse
,
Richard S E Keefe
,
Jennifer Dungan
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DOI
Genetic Basis of Positive and Negative Symptom Domains in Schizophrenia
Schizophrenia is a highly heritable disorder, the genetic etiology of which has been well established. Yet despite significant advances …
Rose Mary Xavier
,
Allison Vorderstrasse
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DOI
Unraveling interrelationships among psychopathology symptoms, cognitive domains and insight dimensions in chronic schizophrenia
Introduction- Insight in schizophrenia is long known to have a complex relationship with psychopathology symptoms and cognition. …
Rose Mary Xavier
,
Wei Pan
,
Jennifer Dungan
,
Richard S E Keefe
,
Allison Vorderstrasse
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DOI
Neurobiological Basis of Insight in Schizophrenia- A Systematic Review
Background-Insight in schizophrenia is defined as awareness into illness, symptoms, and need for treatment and has long been associated …
Rose Mary Xavier
,
Allison Vorderstrasse
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